Medicines From Bacillus

Nattō-derived Bacillus isolates

Nattō-derived Bacillus isolates include nootropics pyrazine and tetramethylpyrazine, as well as the anticoagulant enzyme nattokinase.


Bacillus is utilized in the production of the chemotherapy medicine L-asparaginase. Bacillus subtilis is utilized in the production of hyaluronic acid and α-amylase.

Bacillus megaterium is an important industrial organism. It produces penicillin amidase used to make synthetic penicillin, various amylases used in the baking industry and glucose dehydrogenase used in glucose blood tests. B. megaterium is also used for the production of pyruvate, vitamin B12, drugs with fungicidal and antiviral properties. B. megaterium produces enzymes for modifying corticosteroids, as well as several amino acid dehydrogenases.

Bacillus subtilis can biosynthesize silver nanoparticles. Bacillus badius can be used to cleaves penicillin G to 6-amino penicillanic acid and phenyl acetic acid. Certain Bacillus have mycorrhiza-like activity and potential bioremediation applications.

Bacillus isolates are used industrially as probiotics. Additional Bacillus isolates include gamma-D-Glutamyl-meso-diaminopimelate peptidase, sonorensin, gamma-cyclodextrin, 2,5-diketopiperazines, laccases, bacteriocin, paenicidin A, tridecaptin A₁, and paenicidin B. Bacillus thuringiensis isolates are utilized as biopesticides.